Glial Cell Line-Derived Neurotrophic Factor Induces Cell Proliferation in the Mouse Urogenital Sinus
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چکیده
منابع مشابه
Glial cell line-derived neurotrophic factor induces cell proliferation in the mouse urogenital sinus.
Glial cell line-derived neurotrophic factor (GDNF) is a TGFβ family member, and GDNF signals through a glycosyl-phosphatidylinositol-linked cell surface receptor (GFRα1) and RET receptor tyrosine kinase. GDNF signaling plays crucial roles in urogenital processes, ranging from cell fate decisions in germline progenitors to ureteric bud outgrowth and renal branching morphogenesis. Gene ablation s...
متن کاملThe Effects of Progesterone on Glial Cell Line-derived Neurotrophic Factor Secretion from C6 Glioma Cells
Objective(s)Progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. In recent years, the neuroprotective effects of progesterone have attracted growing interest. Glial cell line-derived neurotrophic factor (GDNF), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
متن کاملکلون کردن cdnaیneurotrophic factor)gdnf(glial cell line-derived در حامل بیانی با قابلیت الحاق هدفمند در ژنوم سلول میزبان
چ فده قیقحت : هدننک دک یلاوت زا یپک ود یاراد ینایب روتکو تخاس هعلاطم نیا زا فده gdnf نایب یارب یناسنا .تسا نارادناتسپ یلولس هدر رد : قیقحت شور cds نیئتورپ gdnf صخشم یکیتامروفناویب تاعلاطم هلیسو هب یناسنا دیدرگ تفج ود کمک اب . اب هک یرمیارپ رازفا مرن oligo7.4 یحارط دندش رد هناشن دیتپپ ، n و نیئتورپ لانیمرت his-tag رد c نآ لانیمرت شور زا هدافتسا اب .تفرگ رارق t/a cloning روتکو رد هدش دی...
Glial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and beta-cell proliferation in the developing mouse pancreas.
Glial cell line-derived neurotrophic factor (GDNF) is a factor produced by glial cells that is required for the development of the enteric nervous system. In transgenic mice that overexpress GDNF in the pancreas, GDNF has been shown to enhance beta-cell mass and improve glucose control, but the transcriptional and cellular processes involved are not known. In this study we examined the influenc...
متن کاملGlial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and -cell proliferation in the developing mouse pancreas
Mwangi SM, Usta Y, Raja SM, Anitha M, Chandrasekharan B, Parsadanian A, Sitaraman SV, Srinivasan S. Glial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and -cell proliferation in the developing mouse pancreas. Am J Physiol Gastrointest Liver Physiol 299: G283–G292, 2010. First published May 6, 2010; doi:10.1152/ajpgi.00096.2010.—Glial cell line-derived neurotrophic ...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2015
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2014-1312